DESCRIPTION

Amiset-AT Tablet (Amlodipine 5 mg  + Atenolol50 mg) is a combination medicine used in the treatment of hypertension (high blood pressure) and angina pectoris (chest pain or chest discomfort). Amiset-AT Tablet (Amlodipine 5 mg  + Atenolol50 mg)  helps to lower your blood pressure, thereby reducing the chances of future heart attack and stroke. 

INDICATION

• Hypertension : Hypertension or high blood pressure occurs when blood vessels in your heart are narrowed leading to decreased pumping of blood to your body. Amiset-AT Tablet (Amlodipine 5 mg  + Atenolol50 mg)  helps in lowering high blood pressure.

• Chronic stable angina : Chronic stable angina is a brief episode of pain, squeezing, pressure, or tightness in the chest caused by heavy physical activity which increases the blood pressure and body’s oxygen demand. Amiset-AT Tablet (Amlodipine 5 mg  + Atenolol50 mg)  is used in the treatment of chronic stable angina.

MECHANISM OF ACTION 

Amlodipine, a calcium channel blocker, works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle. This leads to vasodilation, decreased vascular resistance, lowered blood pressure, and a reduction in the heart's workload.

Atenolol, a beta-1 selective beta-blocker, decreases heart rate and cardiac output by blocking beta-1 adrenergic receptors in the heart. This reduces sympathetic outflow and renin release from the kidneys, further lowering blood pressure.

DRUG INTERACTIONS

Drug-Drug Interactions : Amiset-AT Tablet (Amlodipine 5 mg  + Atenolol50 mg)  is known to interact with potassium-sparing diuretics (amiloride, eplerenone, spironolactone), anti-depression medication (lithium), high blood pressure-lowering pills (benazepril, metoprolol, ramipril, hydrochlorothiazide), drugs used to control lipid levels in the blood (atorvastatin, simvastatin), medicines to treat erectile dysfunction (sildenafil), antibiotics (clarithromycin, erythromycin, rifampin), antifungal (itraconazole, ketoconazole), anti-HIV drugs (ritonavir), anti-epilepsy medicines (carbamazepine, phenytoin, phenobarbital, primidone), immune-suppressing drugs (cyclosporine, tacrolimus) and painkillers (ibuprofen, aspirin).

Drug-Food Interactions : Amiset-AT Tablet (Amlodipine 5 mg  + Atenolol50 mg)  is known to interact with grapefruit juice and alcohol. So, it should not be taken along with the Amiset-AT Tablet.

Drug-Disease Interactions:Amiset-AT Tablet (Amlodipine 5 mg  + Atenolol50 mg)  is known to interact if you have kidney or liver problems, heart disease, diabetes, myasthenia gravis (muscle weakness), glaucoma (increased eye pressure), asthma, hypotension (low blood pressure), cardiogenic shock (when the heart fails to pump required blood to the body).

SIDE EFFECTS OF AMISET-AT TABLET

Major & minor side effects for Amiset-AT Tablet

• Nausea
• Sleepiness
• Ankle swelling
• Headache 
• Palpitations
• Cold extremities
• Flushing (sense of warmth in the face, ears, neck, and trunk)
• Slow heart rate
• Oedema (swelling) 
• Constipation
• Tiredness

PRECAUTIONS

When takingAmiset-AT Tablet (Amlodipine 5 mg  + Atenolol50 mg) , it's important to monitor blood pressure and heart rate regularly to avoid hypotension or bradycardia. Do not abruptly stop atenolol to prevent rebound hypertension or angina. Use cautiously in patients with heart failure and regularly assess liver and kidney function. Be aware of potential drug interactions and monitor blood sugar levels in diabetic patients as atenolol can mask hypoglycemia symptoms. Pregnant or breastfeeding women should consult their healthcare provider. Watch for common side effects like dizziness and edema, and limit alcohol intake to reduce the risk of enhanced side effects. Proper patient education on adherence and lifestyle modifications is crucial for effective treatment.

DISCLAIMER

The information on this website is provided for general informational purposes only and is not medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Consult a qualified healthcare provider for personalized advice. We do not endorse any specific products, treatments, or services mentioned.