DESCRIPTION

Cefjone-O Dry Syrup (Cefixime 50 mg + Ofloxacin 50 mg) is an antibacterial medication used in children to treat typhoid fever, urinary tract infections, skin and soft tissue infections, and lower respiratory tract infections. It is not effective against infections caused by viruses. Cefjone-O Dry Syrup works by killing bacteria and inhibiting the progression of infections.

INDICATION 

• Typhoid fever : Typhoid fever is a bacterial infection caused by Salmonella typhi, which spreads through contaminated food or water from an infected person. Cefjone-O Dry Syrup (Cefixime 50 mg + Ofloxacin 50 mg)  is used to treat typhoid fever. Common side effects may include high fever, loss of appetite, constipation, diarrhea, and vomiting.

• 
  Urinary Tract Infection : A urinary tract infection (UTI) affects any part of the urinary system, including the kidneys, bladder, ureters, or urethra. UTIs are common and women are at a higher risk of developing them. While UTIs are primarily caused by bacteria, they can occasionally be caused by viruses or fungi. Cefjone-O Dry Syrup (Cefixime 50 mg + Ofloxacin 50 mg)  is used to treat UTIs in children that are caused by bacterial infections.

• 
  Skin and Skin Structure Infection : Skin and soft tissue infections occur when bacteria invade the skin and its supporting structures. Cefjone-O Dry Syrup (Cefixime 50 mg + Ofloxacin 50 mg)  is used to treat various skin infections, including abscesses, caused by bacteria.

• 
  Acute bronchitis :  Bronchitis is the inflammation and irritation of the bronchial tubes that carry air to the lungs. Cefjone-O Dry Syrup (Cefixime 50 mg + Ofloxacin 50 mg) is used to treat bronchitis caused by bacterial infections. It is also used to manage acute exacerbations of chronic bronchitis (long-term inflammation of the bronchi) and recurring episodes of bronchitis.

MECHANISM OF ACTION

Cefixime : Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) and blocking the enzyme transpeptidase, which is crucial for peptidoglycan cross-linking. This weakens the cell wall, leading to bacterial death. It has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, making it effective for treating infections such as respiratory and urinary tract infections.

Ofloxacin : Ofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication. By blocking DNA gyrase, it prevents the supercoiling of DNA, which is necessary for replication and transcription. Additionally, inhibiting topoisomerase IV disrupts the separation of intertwined DNA strands. This dual action halts bacterial growth and replication.

SIDE EFFECTS OF CEFJONE-O DRY SYRUP

Major & minor side effects for Cefjone-O Dry Syrup

• Abdominal pain
• Anxiety
• Black or tarry stools
• Diarrhoea
• Fever
•  Decreased appetite
• Joint pain
• Change in taste
• Excessive air or gas in stomach
• Dizziness
• Acid or sour stomach
• Heart burn

DRUG INTERACTIONS

Drug-Drug Interaction : Cefjone-O Dry Syrup (Cefixime 50 mg + Ofloxacin 50 mg) should be avoided to be taken with vaccines including typhoid vaccine, cholera vaccine, and Bacillus Calmette Guerin (BCG vaccine), antiepileptic (carbamazepine), blood thinner (warfarin), antacid and ulcer treating medicine (aluminium hydroxide, magnesium hydroxide, cimetidine, sucralfate), medicine to treat excess uric acid (probenecid), medicines for arthritis (methotrexate), diuretics/water pills (furosemide), asthma medicine (theophylline) and pain killers (fenbufen, ibuprofen). 

Drug-Food Interaction : A person should limit the consumption of eating a high-fat meal as this makes it harder for your body to absorb Cefjone-O Dry Syrup (Cefixime 50 mg + Ofloxacin 50 mg) . Do not consume grapefruit during antibiotics treatment can prevent the body from utilizing Cefjone-O Dry Syrup (Cefixime 50 mg + Ofloxacin 50 mg)  properly. So, prevent intake of grapefruit or grapefruit juice with the antibiotic. Avoid consuming calcium enriched foods and drinks as it might affect the working of Cefjone-O Dry Syrup (Cefixime 50 mg + Ofloxacin 50 mg) . 

Drug-Disease Interaction : People affected with diabetes mellitus, renal dysfunction, liver disease, seizure disorders, colitis (bowel disease that affects the large intestine, causing irritation, inflammation, and ulcers in the colon) should not take Cefjone-O Dry Syrup (Cefixime 50 mg + Ofloxacin 50 mg) .

PREACUTION

When using Cefjone-O Dry Syrup (Cefixime 50 mg + Ofloxacin 50 mg), ensure no allergies exist and monitor for any adverse reactions like rash or swelling. Assess kidney function, especially if impaired, and be cautious of potential tendon issues—avoid strenuous activities and consult a doctor if joint pain occurs. Use the antibiotic only as prescribed to prevent resistance, and complete the full course. Inform your healthcare provider about all medications to avoid interactions, and discuss use during pregnancy or breastfeeding. Additionally, be aware of increased sun sensitivity and use sunscreen accordingly, especially for children.

DISCLAIMER

The information on this website is provided for general informational purposes only and is not medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Consult a qualified healthcare provider for personalized advice. We do not endorse any specific products, treatments, or services mentioned.