DESCRIPTION

Glipotec M1 Tablet (Glimepiride 1 mg + Metformin 500 mg (PR) is  a  combination of two medicines, It helps the patient to treat and cure type 2 diabetes mellitus (DM). It is a mix of Glimepiride and Metformin Hydrochloride that combine and improve the level of glucose in adults. It works more efficiently if used with proper nutrition and daily exercise. Glipotec M1 Tablet (Glimepiride 1 mg + Metformin 500 mg (PR) is recommended as the first line of treatment for those patients who are suffering from type 2 diabetes mellitus (DM).

INDICATION

• Improved Blood Sugar Control : Glipotec M1 Tablet (Glimepiride 1 mg + Metformin 500 mg (PR) can help lower blood sugar levels more effectively than either drug alone. This is especially beneficial for patients whose diabetes is not well controlled with monotherapy (single-drug treatment).

• Reduced Risk of Hypoglycemia : Glipotec M1 Tablet (Glimepiride 1 mg + Metformin 500 mg (PR) can lower blood sugar levels by stimulating insulin release from the pancreas. Metformin, on the other hand, primarily reduces insulin resistance and suppresses glucose production by the liver. Glipotec M1 Tablet (Glimepiride 1 mg + Metformin 500 mg (PR) can mitigate the risk of hypoglycemia (low blood sugar levels).

• Preservation of Pancreatic Function :Glipotec M1 Tablet (Glimepiride 1 mg + Metformin 500 mg (PR) action of stimulating insulin secretion can help maintain the function of pancreatic beta cells by utilizing their insulin production capacity. This is important because progressive beta cell dysfunction is a hallmark of type 2 diabetes.

MECHANISM OF ACTION 

Glimepiride: This is a sulfonylurea that stimulates the pancreas to release insulin. It does so by binding to specific receptors on the pancreatic beta cells, which causes an increase in insulin secretion, thereby helping to lower blood glucose levels.

Metformin: This is a biguanide that primarily works by decreasing hepatic glucose production and increasing insulin sensitivity in peripheral tissues. It enhances the body’s response to insulin and helps lower blood sugar levels without increasing insulin production. Additionally, Metformin slightly reduces glucose absorption from the intestines.

DRUG INTERACTIONS

Drug-Drug Interaction : Glipotec M1 Tablet (Glimepiride 1 mg + Metformin 500 mg (PR) may have interaction with antibiotics (rifampicin, trimethoprim), calcium channel blockers (verapamil), antacids (cimetidine), HIV/AIDS drugs (dolutegravir), heart-related medicine (ranolazine), anticancer drugs (vandetanib, crizotinib, olaparib), antifungals (fluconazole, miconazole), water pill (acetazolamide), antidiabetic drug (insulin), anticonvulsants (phenytoin).

Drug-Food Interaction : Glipotec M1 Tablet (Glimepiride 1 mg + Metformin 500 mg (PR) may interact with alcohol. Therefore, avoid the consumption of alcohol with Glipotec - M1 Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Drug-Disease Interaction: If you have severe infections, uncontrolled diabetes, lactic acidosis or ketoacidosis (accumulation of ketone bodies in the blood), dehydration, or liver or kidney problems, inform your doctor before taking Glipotec - M1 Tablet.

SIDE EFFECTS OF GLIPOTEC-M1 TABLET  TABLET

Major & minor side effects for Glipotec-M1 Tablet

• Stomach pain
• Nausea
• Diarrhoea
• Vomiting
• Headache
• Metallic taste

PRECAUTION

When taking Glipotec M1 Tablet (Glimepiride 1 mg + Metformin 500 mg (PR), it's crucial to observe several precautions. Firstly, be vigilant for signs of low blood sugar (hypoglycemia) due to Glimepiride's ability to lower blood glucose levels. Regular monitoring of blood sugar levels is essential to prevent and manage this risk. Secondly, ensure adequate kidney function before starting this combination, as Metformin is excreted through the kidneys and impaired function can lead to complications such as lactic acidosis. Additionally, monitor liver function regularly, as both medications can affect liver enzymes. Avoid Glipotec M1 if allergic to sulfonylureas or biguanides. Pregnant or breastfeeding individuals should seek medical advice before using these medications. Finally, be cautious with alcohol consumption, as it can exacerbate the risk of hypoglycemia. Always consult healthcare providers regarding potential interactions with other medications and adhere strictly to prescribed dosages and monitoring schedules

DISCLAIMER

The information on this website is provided for general informational purposes only and is not medical advice.. It is not a substitute for professional medical advice, diagnosis, or treatment. Consult a qualified healthcare provider for personalized advice. We do not endorse any specific products, treatments, or services mentioned.