DESCRIPTION

Janprox-SR Tablet (Isoxsuprine 40 mg SR) is used to treat and prevent peripheral vascular disease, a blood circulation disorder where the blood vessels outside of the heart and brain become narrowed. This happens when plaque (fat deposits) builds up in arteries that supply blood to the peripheral parts of the body like arms and legs. Janprox-SR Tablet (Isoxsuprine 40 mg SR) helps in increasing the blood flow in the blood vessels and improves blood circulation. 

INDICATION

• Vasodilation: Janprox-SR Tablet (Isoxsuprine 40 mg SR) relaxes the smooth muscles in blood vessel walls, leading to the widening of blood vessels (vasodilation). This improves blood flow and reduces the resistance against which the heart has to pump.

• Beta-Adrenergic Receptor Activation: It acts as a selective beta-adrenergic agonist, primarily stimulating beta-2 adrenergic receptors. Activation of these receptors results in the relaxation of smooth muscle tissues in blood vessels and the uterus.

• Reduction of Vascular Resistance: By dilating blood vessels, Janprox-SR Tablet (Isoxsuprine 40 mg SR) lowers peripheral vascular resistance. This helps alleviate symptoms of conditions related to poor circulation, such as intermittent claudication.

• Uterine Relaxation: In the uterus, Janprox-SR Tablet (Isoxsuprine 40 mg SR) action on beta-2 adrenergic receptors helps to reduce uterine contractions. This can be beneficial in managing premature labor and uterine irritability.

MECHANISM OF ACTION

Isoxsuprine 40 mg works primarily as a vasodilator through its selective activation of beta-2 adrenergic receptors. By stimulating these receptors, Isoxsuprine induces relaxation of smooth muscle tissues in both blood vessels and the uterus. In blood vessels, this relaxation leads to vasodilation, which reduces vascular resistance and enhances blood flow, thereby improving circulation in conditions like peripheral vascular disease. In the uterus, Isoxsuprine’s action helps to decrease uterine contractions, making it useful in managing premature labor and uterine irritability. Overall, Isoxsuprine's mechanism involves promoting smooth muscle relaxation, which contributes to better blood flow and reduced uterine tone.

DRUG INTERACTIONS

Drug-Drug Interactions: Janprox-SR Tablet (Isoxsuprine 40 mg SR) interacts with some medicines, so it should be used with caution with antibiotics (erythromycin, clarithromycin or rifampicin), antifungal  (ketoconazole), anti-hypertensive (diltiazem, lovastatin, simvastatin, atorvastatin),  anti-migraine (ergotamine, dihydroergotamine), sedatives or hypnotics (buspirone), certain antidepressants (fluoxetine and lithium), medicines to lower blood pressure (methyldopa), anti-Parkinson’s (levodopa, pramipexole, ropinirole), anti-epilepsy (phenobarbital, carbamazepine, phenytoin, rifampicin, primidone, oxcarbazepine, ethosuximide, valproate).

Drug-Food Interactions: Please tell your doctor about all the Vitamins, herbs, and supplements you are taking as Janprox-SR Tablet (Isoxsuprine 40 mg SR) may interact with them to produce unpleasant side effects. 

Drug-Disease Interactions: Janprox-SR Tablet (Isoxsuprine 40 mg SR) should be taken with caution in people who have low blood pressure, a bleeding problem, especially arterial bleeding, have had a heart attack or any heart problem.

SIDE EFFECTS JANPROX-SR TABLET

Major & minor side effects for Janprox-SR Tablet

• Weakness
• Dizziness
• Flushing (feeling of warmth)
• Upset stomach
• Vomiting
• Stomach pain

PRECAUTIONS

When using Isoxsuprine 40 mg, several precautions should be considered. Individuals with cardiovascular conditions, such as heart disease or hypertension, should use this medication cautiously, as vasodilation can potentially affect blood pressure and heart function. Patients with diabetes should monitor their blood sugar levels regularly, as Isoxsuprine may influence glucose metabolism. Those with a history of allergic reactions to the medication or similar drugs should consult their healthcare provider before use. Pregnant or breastfeeding women should seek medical advice to ensure the medication's safety and appropriateness. Additionally, Isoxsuprine can interact with other medications, so it is important to inform your healthcare provider of all current prescriptions and over-the-counter drugs. Regular monitoring by a healthcare provider is recommended to manage any potential side effects and to ensure the medication is effectively addressing the condition.

DISCLAIMER

The information on this website is provided for general informational purposes only and is not medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Consult a qualified healthcare provider for personalized advice. We do not endorse any specific products, treatments, or services mentioned.