DESCRIPTION

Meflom Suspension is a combination medicine that consists of (Mefenamic acid and Paracetamol). It is used to provide relief from the pain associated with toothaches, backaches, sprains, strains and musculoskeletal pain with or without fever. Meflom Suspension (Mefenamic acid and Paracetamol) decreases the intensity of pain signals to the brain and prevents the release of substances in the brain that causes pain and fever. Meflom Suspension (Mefenamic acid and Paracetamol) can cause side effects like nausea, vomiting, heartburn, stomach pain, loss of appetite, and diarrhoea. Consult your doctor if these symptoms persist or bother you. Do not use this medicine if you are allergic to it. Avoid driving a vehicle or operating machines after taking this medicine as it may affect your vision. Meflom Suspension (Mefenamic acid and Paracetamol) should be taken with food to avoid stomach irritation. Do not use this medicine in your pregnancy or breastfeeding without consulting your doctor. Avoid consuming alcohol while using this medicine as it may cause excessive drowsiness and stomach lining damage. 

INDICATION

• Mild to moderate pain: Pain and inflammation (swelling) are very common conditions that occur as a result of the body's immune response to protect itself against infection, injury, or health problems. Meflom Suspension (Mefenamic acid and Paracetamol) is used to relieve headache, toothache, backache, and musculoskeletal (muscles and bones) pain associated with/without fever. Meflom Suspension (Mefenamic acid and Paracetamol) blocks the action of chemical messengers that are responsible for pain.

• Fever: A fever is a temporary increase in your body temperature, often due to an illness. Meflom Suspension (Mefenamic acid and Paracetamol) provides temporary relief from fever without treating the underlying cause
 

MECHANISM OF ACTION

Paracetamol (250 mg): Paracetamol is primarily a central acting analgesic and antipyretic, with minimal anti-inflammatory effects. Its exact mechanism is not completely understood, but it is believed to work mainly through the inhibition of COX enzymes in the central nervous system (CNS), particularly COX-2, which reduces the synthesis of prostaglandins. Prostaglandins play a key role in causing pain, inflammation, and fever, so their reduction helps alleviate pain and lower body temperature in feverish conditions. Additionally, some studies suggest that paracetamol may activate the endocannabinoid system, contributing to its analgesic effects by modulating pain and mood regulation. Paracetamol may also interact with serotonergic pathways, particularly through 5-HT3 receptors, enhancing its pain-relieving properties, especially in conditions like headaches. Overall, paracetamol is effective for mild to moderate pain and fever but lacks significant anti-inflammatory action, limiting its use for conditions with considerable inflammation.

Mefenamic Acid (100 mg): Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that exerts its effects by inhibiting both COX-1 and COX-2 enzymes, which are involved in the production of prostaglandins. By blocking these enzymes, mefenamic acid reduces the synthesis of prostaglandins at the site of inflammation, thereby alleviating pain, reducing inflammation, and lowering fever. This makes mefenamic acid particularly effective in treating conditions such as musculoskeletal pain or dysmenorrhea (painful menstruation). The inhibition of COX enzymes also provides anti-inflammatory effects, helping to reduce swelling, redness, and pain at the site of injury or infection. In addition to its anti-inflammatory action, mefenamic acid has analgesic and antipyretic properties, providing pain relief and fever reduction by blocking prostaglandins in the hypothalamus, which helps regulate body temperature.
 

SIDE EFFECTS OF MEFLOM SUSPENSION

Major & minor side effects for Meflom Suspension 

• Nausea or Vomiting
• Allergic skin reaction
• Mouth sores
• Bloody and cloudy urine
• Diarrhoea
• Constipation
• Headache
• Ringing or buzzing in the ears
• Blurred vision
• Weight gain
• Shortness of breath
• Swelling of face, lips, eyelids, tongue, hands and feet 
• Fast heartbeat
• Yellow colored eyes or skin
• Difficult or painful urination
• Excessive tiredness

DRUG INTERACTIONS

Drug-Drug Interactions: Meflom Suspension (Mefenamic acid and Paracetamol) may interact with pain killers (aspirin, ibuprofen, celecoxib, diclofenac, naproxen), anti-gout (probenecid), immunosuppressants (cyclosporine, tacrolimus), anticoagulants (warfarin, heparin), anti-rheumatoid (methotrexate), anti-HIV (zidovudine), anti-depressant (duloxetine, lithium, fluoxetine, sertraline), steroid medication (mifepristone), anti-emetic (metoclopramide, domperidone), anti-cancer (imatinib), and bile acid sequestrants (cholestyramine).

Drug-Food Interactions: Avoid alcohol consumption while taking Meflom Suspension (Mefenamic acid and Paracetamol) as it might cause increased dizziness and risk of stomach bleeding.

Drug-Disease Interactions: Inform your doctor if you have peptic ulcers, bleeding disorders, asthma, fluid retention, gastrointestinal toxicity, rash, renal toxicity, thrombosis, anaemia, heart failure, liver toxicity, high blood pressure, platelet aggregation inhibition, or hyperkalemia (high potassium levels).

PRECAUTIONS

When using Meflom Suspension (Paracetamol 250 mg + Mefenamic Acid 100 mg) together, caution is necessary in patients with liver or kidney problems, as both drugs can affect these organs. Paracetamol should be used carefully in individuals with liver disease, and Mefenamic Acid, being an NSAID, may cause gastrointestinal issues, including ulcers and bleeding, especially in those with a history of GI disorders. Both drugs can interact with anticoagulants, increasing the risk of bleeding. Elderly patients and those with cardiovascular or renal conditions should be closely monitored. Mefenamic acid is contraindicated in the third trimester of pregnancy and should be used cautiously in early pregnancy. Overuse or exceeding recommended doses of either drug can lead to serious complications like liver damage or kidney failure.

DISCLAIMER
 

The information on this website is provided for general informational purposes only and is not medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Consult a qualified healthcare provider for personalized advice. We do not endorse any specific products, treatments, or services mentioned.