DESCRIPTION

Pesak Plus Suspension is a combination (Aceclofenac 50 mg + Paracetamol 125 mg Suspension) medication designed to provide relief from pain, inflammation, and fever. The active ingredient Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that works by reducing inflammation, pain, and swelling, making it effective for conditions like arthritis, muscle pain, and back pain. Paracetamol (also known as acetaminophen) is an analgesic and antipyretic that helps relieve mild to moderate pain and reduce fever but does not have anti-inflammatory effects. Pesak Plus Suspension is a combination of (Aceclofenac and Paracetamol) offers a synergistic approach to managing pain and inflammation, making it suitable for musculoskeletal pain, headaches, post-surgical pain, and fever associated with various illnesses. Pesak Plus Suspension (Aceclofenac and Paracetamol) form of the medication is particularly helpful for children or individuals who have difficulty swallowing tablets. Always follow the prescribed dosage and consult with a healthcare provider for proper use.

INDICATION

• Musculoskeletal Pain: Pesak Plus Suspension (Aceclofenac and Paracetamol) as an NSAID, is highly effective in relieving pain caused by inflammation in the muscles, bones, and joints. Pesak Plus Suspension (Aceclofenac and Paracetamol) includes conditions like back pain, muscle sprains, ligament strains, or pain from musculoskeletal injuries.
  
   
• Arthritis Pain: Pesak Plus Suspension (Aceclofenac and Paracetamol) helps to reduce joint inflammation, making it useful for treating pain associated with osteoarthritis and rheumatoid arthritis. Pesak Plus Suspension (Aceclofenac and Paracetamol) combination of Aceclofenac with Paracetamol helps to manage both the pain and discomfort caused by joint stiffness and inflammation.
  
   
• Toothache: The anti-inflammatory properties of Aceclofenac, along with the pain-relieving effect of Paracetamol, make Pesak Plus Suspension (Aceclofenac and Paracetamol) combination effective for relieving dental pain, including pain following dental procedures.
  
   
• Post-Surgical Pain: After surgery, inflammation and pain are common. Pesak Plus Suspension (Aceclofenac and Paracetamol) suspension provides relief from postoperative pain by reducing inflammation and offering analgesic effects.

• Fever Management: Pesak Plus Suspension (Aceclofenac and Paracetamol) in the combination acts as an effective antipyretic (fever reducer). Pesak Plus Suspension (Aceclofenac and Paracetamol) helps lower high body temperature, which is common in conditions like the common cold, flu, and various infections. When combined with Aceclofenac, it provides comprehensive relief from both pain and fever.
  
   
• Post-Infection Fever: After an infection, patients may experience lingering fever. The Paracetamol component of Pesak Plus Suspension (Aceclofenac and Paracetamol) combination is effective at controlling fever, while Aceclofenac addresses any residual inflammation or muscle aches.

• Inflammatory Conditions: The anti-inflammatory properties of Aceclofenac make it suitable for conditions where inflammation is a significant factor. Pesak Plus Suspension (Aceclofenac and Paracetamol) includes disorders such as bursitis, tendinitis, gout, or any soft tissue injuries where inflammation and swelling are present.
  
   
• Osteoarthritis and Rheumatoid Arthritis: For patients with chronic inflammatory conditions like arthritis, Pesak Plus Suspension (Aceclofenac and Paracetamol) combination can provide both relief from pain and help reduce swelling in the affected joints, improving mobility and reducing stiffness.

• Migraine Relief: While not a first-line treatment, Pesak Plus Suspension (Aceclofenac and Paracetamol) combination may be used as an adjunct for pain relief during mild migraine attacks, offering a dual mechanism of action for both pain relief and inflammation control.

MECHANISM OF ACTION 

Aceclofenac (50 mg) - Non-Steroidal Anti-Inflammatory Drug (NSAID):

• Inhibition of Cyclooxygenase (COX): Aceclofenac works by inhibiting the action of cyclooxygenase enzymes (COX-1 and COX-2). These enzymes are responsible for the synthesis of prostaglandins, which are chemicals that promote inflammation, pain, and fever in the body.
  
  
  • COX-1: Primarily involved in maintaining normal physiological functions such as protecting the stomach lining and supporting kidney function.
  • COX-2: Induced during inflammation and injury, contributing to pain, swelling, and fever.
    
     
• Reduction of Prostaglandin Synthesis: By inhibiting COX enzymes, Aceclofenac reduces the production of prostaglandins at the site of inflammation. This results in decreased pain, reduced inflammation, and lowered fever. It is particularly effective in treating conditions such as arthritis, musculoskeletal pain, back pain, and inflammatory disorders.
  
   
• Anti-inflammatory and Analgesic Effects: Aceclofenac's ability to block prostaglandin production leads to reduced swelling and pain at the affected site. It helps in conditions where inflammation is the primary cause of discomfort (e.g., arthritis, muscle strains).

Paracetamol (125 mg) - Analgesic and Antipyretic:

• Central Action in the Brain: Unlike NSAIDs, Paracetamol (acetaminophen) works primarily in the central nervous system (CNS), particularly in the brain. It is thought to inhibit a form of cyclooxygenase (COX-3) in the brain, which may contribute to the regulation of pain and temperature.
  
   
• Pain Relief (Analgesic Effect): Paracetamol reduces the perception of pain by blocking the production of prostaglandins in the brain and spinal cord. It is particularly effective for relieving mild to moderate pain, such as headaches, muscle pain, toothaches, and other non-inflammatory pain.
  
   
• Fever Reduction (Antipyretic Effect): Paracetamol works by acting on the hypothalamus, the part of the brain that regulates body temperature. By inhibiting prostaglandin production in the hypothalamus, Paracetamol helps to lower elevated body temperature, providing relief from fever caused by infections or other conditions.

SIDE EFFECTS OF PESAK PLUS SUSPENSION

Major & minor side effects for Pesak Plus Suspension

• Dizziness
• Nausea
• Digestion problems (like constipation, flatulence, diarrhoea)
• Increased liver enzymes in the blood (diagnosed through liver function test)

DRUG INTERACTIONS

Drug-Drug Interaction: Pesak Plus Suspension is a combination (Aceclofenac + Paracetamol Suspension) interact with cholesterol lowering drugs (cholestyramine), charcoal, medicine to stop vomiting (domperidone, metochlopramide), alcohol, anti HIV drug (zidovudine), blood thinner (warfarin), blood pressure lowering medicine, anti cancer or anti arthritis drug (methotrexate) may lead to drug toxicity or affect the working of Pesak Plus Suspension is a combination( Aceclofenac + Paracetamol Suspension). So, contact the doctor before taking these medicines.

Drug-Food Interaction: No interaction found.

Drug-Disease Interaction: Patient affected with liver disease, bleeding disorder and alcoholism should not take  Pesak Plus Suspension is a combination (Aceclofenac + Paracetamol Suspension) as it has a risk of causing derangement in liver functions.

PRECAUTIONS

When using Pesak Plus Suspension is a combination (Aceclofenac + Paracetamol Suspension), caution is required in individuals with a history of gastric ulcers, liver disease, or kidney impairment, as both active ingredients can affect gastrointestinal, liver, and kidney function. The combination should be avoided in the third trimester of pregnancy and used with care during the first two trimesters, while breastfeeding should be discussed with a doctor due to potential excretion in breast milk. Children under 12 should use the suspension under medical supervision, with proper dosage adjustments. Elderly patients and those with cardiovascular conditions should be closely monitored for any adverse effects, such as fluid retention or increased blood pressure. It is also important to avoid alcohol while using this medication, as it can increase the risk of liver toxicity. Always consult a healthcare provider before starting the treatment, particularly if other medications are being used concurrently.

DISCLAIMER

The information on this website is provided for general informational purposes only and is not medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Consult a qualified healthcare provider for personalized advice. We do not endorse any specific products, treatments, or services mentioned.