DESCRIPTION

Tazo-P Injection (Piperacillin and tazobactam) should be used with caution in patients with a history of allergic reactions to penicillins or other beta-lactam antibiotics, as hypersensitivity reactions, including anaphylaxis, can occur. It should also be carefully administered in patients with renal impairment, as dose adjustments may be required to prevent toxicity. Patients with a history of gastrointestinal disease, particularly colitis, should be monitored closely, as antibiotic therapy can disrupt normal gut flora and lead to Clostridium difficile-associated diarrhea. Additionally, the combination may interact with other medications, such as anticoagulants, requiring monitoring of coagulation parameters. Regular monitoring of renal function and liver enzymes is recommended during treatment.

INDICATION

1. Community acquired pneumonia : Community-acquired pneumonia (CAP) refers to pneumonia (lung infection) that is acquired outside the hospital. CAP can be bacterial or viral. Tazo-P Injection(Piperacillin (4000 mg) + Tazobactam (500 mg) is used to treat CAP caused by bacteria Haemophilus influenzae. Nosocomial Pneumonia or Hospital-acquired Pneumonia (HAP). Nosocomial Pneumonia refers to pneumonia (lung infection) that is acquired in the hospital. Tazo-P InjectionPiperacillin (4000 mg) + Tazobactam (500 mg) is used to treat HAP caused by the bacteria Staphylococcus aureus, Haemophilus influenzae, Klebsiella pneumoniae, etc.
   
    
2. Urinary Tract Infection : Urinary Tract Infection is an infection in any part of your urinary system. It may affect your kidneys, bladder, or urethra. Symptoms may include increased urge to urinate, pain during urination, blood in the urine, back pain, nausea, vomiting, fever, etc. Tazo-P Injection (Piperacillin (4000 mg) + Tazobactam (500 mg) is used in the treatment of urinary tract infection.
   
    
3. Intra abdominal infection : Intra-abdominal infection is a broad term that includes a number of infections of the organs of the abdomen. It includes peritonitis (swelling of the lining of the abdominal wall), diverticulitis (swelling of diverticula- one or more small pouches in the intestine), cholecystitis (swelling of the gallbladder), cholangitis (swelling of the bile duct system), and pancreatitis (swelling of the pancreas). Tazo-P  Injection (Piperacillin (4000 mg) + Tazobactam (500 mg) is used in the treatment of these infections.
   
    
4. Skin and Skin Structure Infection : Tazo-P Injection (Piperacillin (4000 mg) + Tazobactam (500 mg) is used in the treatment of skin and skin structure infections such as cellulitis (serious bacterial skin infection, usually affecting lower legs), cutaneous abscesses (skin infection with the presence of pus), and diabetic foot infections (foot infection due to diabetes) caused by bacteria Staphylococcus aureus.
   
    
5. Bacterial Septicaemia : Septicaemia, also known as blood poisoning is a serious infection of the blood. It occurs when a bacterial infection in any part of the body (such as the lungs or the skin) enters the bloodstream. Tazo-P  Injection (Piperacillin (4000 mg) + Tazobactam (500 mg)is used in the treatment of bacterial septicaemia.
   
    
6. Neutropenia : Neutropenia is a condition with decreased number of neutrophils, a type of white blood cell that helps fight infections in your body. Neutropenia increases your risk of developing infections.  Tazo-P  Injection (Piperacillin (4000 mg) + Tazobactam (500 mg) is used in the treatment of fever associated with neutropenia.

MECHANISM OF ACTION

Piperacillin (4000 MG) : It is effective against a wide range of both gram-positive and gram-negative bacteria. However, many bacteria produce beta-lactamases—enzymes that break down the beta-lactam ring structure of piperacillin and render it ineffective. To overcome this, piperacillin is often combined with a beta-lactamase inhibitor, such as tazobactam, which protects the antibiotic from degradation and broadens its spectrum of activity against beta-lactamase-producing bacteria.

Tazobactam : It is a beta-lactamase inhibitor that works by binding to and inactivating beta-lactamase enzymes produced by certain bacteria. Beta-lactamases are enzymes that hydrolyze the beta-lactam ring of antibiotics like penicillins and cephalosporins, rendering them ineffective. By inhibiting these enzymes, tazobactam prevents the breakdown of beta-lactam antibiotics, such as piperacillin, thereby enhancing their antimicrobial activity.

SIDE EFFECTS OF TAZO- P INJECTION

Major & minor side effects for Tazo- P Injection

• Diarrhoea
• Headache
• Sleeplessness
• Abdominal pain
• Nausea and Vomiting
• Stomach upset
• Skin rash and itching
• Fever
• Injection site reactions (redness, pain, swelling)
• Joint and muscle pain

DRUG INTERACTIONS

Drug-Drug Interaction: Tazo-P Injection (Piperacillin+Tazobactam) may interact with anticoagulants (heparin), anti-cancer drugs (methotrexate), antibiotics (tobramycin, vancomycin), gout medicines (probenecid), and anaesthetic drugs (vecuronium).

Drug-Food Interaction: Avoid alcohol consumption while taking Tazo-P Injection (Piperacillin+Tazobactam) to prevent unpleasant side-effects, such as nausea and vomiting.

Drug-Disease Interaction: Before taking Tazo-P Injection (Piperacillin+Tazobactam), let your doctor know if you have cystic fibrosis, kidney disease, fits, colitis, bleeding disorders, heart or liver diseases, and are undergoing dialysis treatment.           

PRECAUTIONS

Tazo-P  Injection (Piperacillin (4000 mg) + Tazobactam (500 mg) should be used with caution in patients with a history of allergic reactions to penicillins or other beta-lactam antibiotics, as hypersensitivity reactions, including anaphylaxis, can occur. It should also be carefully administered in patients with renal impairment, as dose adjustments may be required to prevent toxicity. Patients with a history of gastrointestinal disease, particularly colitis, should be monitored closely, as antibiotic therapy can disrupt normal gut flora and lead to Clostridium difficile-associated diarrhea. Additionally, the combination may interact with other medications, such as anticoagulants, requiring monitoring of coagulation parameters. Regular monitoring of renal function and liver enzymes is recommended during treatment.

DISCLAIMER

The information on this website is provided for general informational purposes only and is not medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Consult a qualified healthcare provider for personalized advice. We do not endorse any specific products, treatments, or services mentioned.