DESCRIPTION

Tenesys-M Tablet (Teneligliptin 20 mg + metformin 500 mg) is a combination medication used to manage type 2 diabetes mellitus. Teneligliptin, a DPP-4 inhibitor, increases insulin secretion and reduces glucagon levels, while metformin, a biguanide, decreases hepatic glucose production and improves insulin sensitivity. Together, they enhance glycemic control more effectively than either drug alone.

INDICATION

• Management of Type 2 Diabetes Mellitus : Tenesys-M Tablet (Teneligliptin 20 mg + metformin 500 mg) as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.

• Combination Therapy : For patients who require multiple medications to achieve adequate blood glucose control when monotherapy is insufficient.

• Enhanced Glycemic Control : Provides improved blood sugar regulation through the complementary mechanisms of teneligliptin and metformin.

MECHANISM OF ACTION 

Teneligliptin 

• Dipeptidyl Peptidase-4 (DPP-4) Inhibitor: Teneligliptin works by inhibiting the enzyme DPP-4, which breaks down incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By prolonging the activity of GLP-1 and GIP, teneligliptin enhances insulin secretion from the pancreas in response to meals. It also reduces the secretion of glucagon, a hormone that raises blood glucose levels by promoting glucose production in the liver. These actions collectively help lower blood glucose levels and improve overall glycemic control.

Metformin 

• Biguanide Class: Metformin primarily works by decreasing hepatic glucose production. It enhances insulin sensitivity in peripheral tissues, leading to improved glucose uptake and utilization. Additionally, metformin minimizes glucose absorption from the intestine, further aiding in blood glucose control. Unlike teneligliptin, metformin does not increase insulin secretion, thus reducing the risk of hypoglycemia.

SIDE EFFECTS OF TENESYS-M TABLET

Major & minor side effects for Tenesys-M Tablet

• Diarrhea,
• Nausea, 
• Vomiting, 
• Hypoglycemia (low blood glucose level),
•  Decreased appetite, 
• Abdominal bloating, Flatulence, 
• Constipation

DRUG INTERACTIONS

Drug-Drug Interactions: Tenesys-M Tablet (Teneligliptin 20 mg + metformin 500 mg) may have an interaction with medicines used to treat bacterial infections (rifampicin, tetracycline, Clarithromycin), a medicine used to treat fungal infections (fluconazole), other oral antidiabetics, medicines used to treat gout (probenecid).

Drug-Food interactions: Intake of excess alcohol may increase the chance of a life-threatening condition known as lactic acidosis.

Drug-Disease Interactions: Tenesys-M Tablet (Teneligliptin 20 mg + metformin 500 mg) should be avoided in patients with heart diseases (congestive heart failure and myocardial infarction), vitamin B12 deficiency, alcoholism, type I diabetes, bladder cancer, oedema (fluid retention), liver disease, premenopausal anovulation, obesity (weight gain), anaemia should avoid intake of Tenesys-M Tablet.

PRECAUTION

When taking a Tenesys-M Tablet (Teneligliptin 20 mg + metformin 500 mg), it is important to monitor your blood sugar levels regularly to avoid hypoglycemia or hyperglycemia. Take the medication with meals to reduce gastrointestinal side effects. Staying hydrated is essential to help prevent dehydration, especially if you experience diarrhea. Additionally, inform your doctor of any other medications you are taking to avoid potential interactions.

DISCLAIMER

The information on this website is provided for general informational purposes only and is not medical advice.. It is not a substitute for professional medical advice, diagnosis, or treatment. Consult a qualified healthcare provider for personalized advice. We do not endorse any specific products, treatments, or services mentioned.